Retour à la page précédente

Prof. Dr. Marc Mathieu

Professeur·e HES
Formations Chimiste, Dr
Bureau ENP 19.N304

Dr. Mathieu's has over 20 years of experience in the Peptide Drug discovery Field, mainly focusing on peptide chemoselective conjugation, peptidic linkers, branched peptides and peptidomimetics. He worked for 10 years in the peptide pharma industry with responsabilities in custom manufacturing, investigation of novel synthetic routes (creating IP value) and all related analytical/scale-up processes.

Dr. Mathieu gives lectures in Chemistry and biochemistry. He is member of the Peptide and Protein Technology research group and his current responsibilities include the state-of-the art peptide laboratory.


Find in section "Documents" the presentation of our Peptide & Peptidomimetics Platform


Representative Publications (co-author)

  • New Protein Mimetics: The Zinc Finger Motif as a locked-in Tertiary Fold
    Angew. Chem. Int. Ed. Engl. 37(21), 2990-2993 (1998)
  • Novel synthetic strategy for the synthesis of template-assembled analogues of rat relaxin
    J. of Peptide Sci. 6, 235-242 (2000)
  • Synthesis, conformational studies and biological activity of Nalpha-mono-biotinylated rat relaxin
    J. Peptide Res. 57(5), 374-382 (2001)
  • Cell-permeable peptides induce dose- and length-dependant cytotoxic effects
    Biochim Biophys Acta. 1768 (9), 2222-2234 (2007)
  • The nNOS-p38MAPK pathway is mediated by NOS1AP during neuronal death
    J Neurosci. 8;33(19),185-201 (2013)
  • Solid-phase synthesis of benzimidazole N-oxides on SynphaseTM lanterns
    Tetrahedron Lett. 44, 2293-2296 (2003)
  • Comparison between a linear ion trap and a triple quadrupole MS in the sensitive detection of large peptides at femtomole amounts on column
    Journal of Separation Science, 33 (16), 2478-2488 (2010)
  • Chemical Modification of Polyhydroxyalkanoates (PHAs) for the preparation of Hybrid Biomaterials
    Chimia, 69 (10), 627-630 (2015)
Mathieu Marc