In the context of an aging society and an increasing number of patients with chronic diseases, a shift of paradigm is needed towards a sustainable management of health, in order to enhance: early detection and prevention of diseases, healthy behaviors & nutrition, patient empowerment & health literacy, seamless and coordinated care, chronic disease management, socially integrated care and independent living and rehabilitation. The Health Technology Innovation Center of the HES-SO Valais-Wallis is an interdisciplinary Center for Sustainable Health Technology Development. Its value chain is based on the following strategic axes: molecular diagnostic assay and systems development, sensor developments & integrated devices, eHealth applications & data analysis and healthy food.